The Buffalo Bill Historical Center is governed by a board of trustees that currently includes forty-six members from Cody area and from across the country.
| Barron G. Collier, II, Chairman | Henry H.R. “Hank” Coe, Jr., Vice Chair |
| Margaret W. “Maggie” Scarlett, Vice Chair | Naoma J. Tate, Vice Chair |
| Mary Gooch Armour | Wallace H. “Wally” Johnson |
| Gordon H. Barrows | William L. “Bill” King |
| Daniele D. Bodini | David M. Leuschen |
| Wiley T. Buchanan, III | Patrick R. “Pat” McDonald |
| John R. “Jack” Caldwell | Willis McDonald, IV |
| Paul V. Cali | Henry P. “Rip” McIntosh, IV |
| Denis Carroll | James E. “Jim” Nielson |
| Richard B. “Dick” Cheney | Nancy D. Petry |
| Edward P. Connors | Harold C. “Hal” Ramser, Jr. |
| Steven R. “Steve” Cranfill | William B. “Bill” Ruger, Jr. |
| Mary Anne Dingus | William N. “Bill” Shiebler |
| Joan C. Donner | Alan K. “Al” Simpson |
| Forrest Fenn | Colin M. Simpson |
| Mary Flitner | H. Leighton Steward |
| Charles C. Francis | John C. Sullivan |
| William C. “Bill” Garlow | Michael J. “Mike” Sullivan |
| Ernest J. “Ernie” Goppert, Jr. | James G. “Jim” Taggart |
| Thomas P. Grainger | Harold E. “Hal” Wackman |
| C. Harris Haston | Margo Grant Walsh |
| Deborah Goppert Hofstedt | Richard Walje |
| Ray L. Hunt | Samuel B. “Sam” Webb, Jr. |